Atul Gawande on his book, Complications: A Surgeon’s Notes on an Imperfect Science stated that: “We look for medicine to be an orderly field of knowledge and procedure. But it is not. It is an imperfect science, an enterprise of constantly changing knowledge, uncertain information, fallible individuals, and at the same time lives on the line. There is science in what we do, yes, but also habit, intuition, and sometimes plain old guessing. The gap between what we know and what we aim for persists. And this gap complicates everything we do.”
It is with no doubt that the field of medicine is a world that is full of mystery. This will lead us to tom the use of multiple approaches to the very same illness. This is since we have no other way of searching for the exact mechanisms in the body. Lengout and Voltaren are two of the medicines of that kind.
This article wishes to explain the use of Lengout and Voltaren for gout and hyperuricemia. Not just that, included also here are their mechanism of actions. Also, you will also be enlightened as to what will happen if you take them together.
Lengout and Voltaren: What do these two have in common?
Lengout and Voltaren are both beneficial in treating pain and inflammation. The Lengout is only beneficial for the gout condition. Lengout is actually a brand name for the colchicine, on the other hand, the Voltaren is a brand name for the diclofenac.
Voltaren, a Diclofenac
Voltaren is a diclofenac, a part of the NSAID, or a Non-Steroidal Anti-inflammatory Drug. As the name suggests, one may presume that it’s used in treating inflammation. In order to understand how the Voltaren does this, just imagine a Lego brick. These Lego bricks are being attached to each other via putting the teeth of the brick to the bottom part of the other.
Now, what if we are to put a small piece of fabric between them? Certainly, it’ll be hard to attach them together. This very same mechanism goes for the Voltaren. It in fact, subjugates the active spot in the cox-1 and cox-2 enzymes where the arachidonic acid perfectly fits. If the arachidonic acid cannot go well with it, they’ll not react and will not be able to produce some other enzymes to increase the alarm signals in the body thus removing the pain and inflammation. The side effect here is that, it may disrupt some other enzymes too.
Lengout, a Colchicine
Lengout is a colchicine, which is a part of the mitotic inhibitor. It actually constrains the cell reproduction. This just means that there’ll be lesser neutrophils that may attack the uric acid crystals in the joints. Through this way, the neutrophils will not be capable of sending any alarm signals. This is because they will fail in immersing the crystal. Therefore, it doen’t causes any inflammations or even pain.
Furthermore, the Lengout does this through the bonding with the microtubules, or the cells’ skeleton. Moreover, this may also disable the capacity of the neutrophils to change its own shape to be able to try overwhelming the uric acid crystals. This particular approach is so effective in getting rid of the pain, yet may have a lot of side effects.
The immune system may be stifled, since the neutrophils are important components of this particular system. Furthermore, the colchicine particles aren’t that smart to differentiate the neutrophils from the other cells. This will consequently disrupt the reproduction of cells in the body! This may cause low sperm cell count, hair loss, and many others!
Lengout and Voltaren if taken together…
Let us have a bit recap of how does the two medications really work:
The Lengout disrupts the mitosis, as well as overwhelming the process of the neutrophils. On the other hand, the Voltaren disturbs the cox-1 and cox-2 enzymes, so that they’ll not be produced, this includes when the neutrophils fail in devouring any foreign affluences.
Therefore, the Lengout and Voltaren has dissimilar entry points. Nevertheless, this isn’t really productive. There is no problem if you take them together. Even though the effect will be much lesser than with the increasing of the dosage of one.
Furthermore, you may also try some other approaches in treating gout. Well, one is removing the acidosis, you may cure gout at once!