The Effects Of Allopurinol On The Liver


Many modern day medications have already advanced to a certain rate that most of the modern illnesses already have a mortal enemy in the form of a medicine. Unhappily, it progressed so fast that the understanding of its own deadly side effects is being left too far behind.

In contrast to the popular belief, even the most communal medication that we use may damage us. A lot were deprived of their lives merely because medications are being released even though its side effects are not yet known and then being withdrawn from the market.

Furthermore, there are some drugs that remain in circulation in the market, in spite of their deadly side effects since no other solution is accepted hitherto. All of the side effects of these drugs are as lethal as those who were withdrawn from the market. One example of which is the side effects of allopurinol. The liver disease severe skin conditions, and hypersensitivity syndromes are just some of the many deadly effects of the drug. This article wishes to explain the side effects of allopurinol that affects the liver.

The Liver

The liver is an organ that is considered as the bustling industrial zone that’s filled with both the manufacturing and processing plants and warehouses. It’s responsible for the filtering of the blood through the segregation of the usable and waste product, which enters the liver. The usable products are being segregated again by kind. For example, the sugar is polished into glucose and is being redistributed to the body for usage. The excessive amount of glucose as well as the nutrients are temporarily being stored in the liver for the future use. The toxic and unusable products are being sent away to the urinary tract in order for it to be excreted out of the body.

The Side Effects Of Allopurinol In The Liver

Allopurinol, basically adds to the burden of the liver and the kidneys. However, this is just a minor effect. The allopurinol is a xanthine oxidase inhibitor. This just means that it is capable of bonding with the xanthine oxidase, the enzyme that bonds with the purine. It actually competes with the purine so the purine will not be broken down into uric acid. The allopurinol is actually an attention seeker that reacts with the purine xanthine oxidase so it’ll not react with the purine.

You might as, where does purine go? Well, it’ll return to the blood stream. The purine is significant as a building block of the body so it isn’t considered as a trash by the liver. The concentration of the purine isn’t reduced, however, the concentration of the xanthine oxidase is being reduced. Since purine is still available, the liver will keep on pumping xanthine oxidase in order to break it down. The liver may not produce loads of xanthine oxidase instantly, that’s the reason why the allopurinol overpowers the purine temporarily and lowers the production of uric acid.

In simple terms, the allopurinol cheats the system and overloads the liver. This is just the start of the side effects of allopurinol. The liver damage may arise here. Furthermore, more damage will start too, just as the homeostatic turbulences in the regulation of the pH level balance of the blood. The liver condition will also cause morose diseases such as TEN.

Furthermore, the allopurinol may cause hepatotoxicity and may cause chronic or acute liver disease eventually. This may occur in different ways.


Foreign substances are sequestered by macrophages who are actually responsible for the elimination of the foreign substances in the body. It’s still vague what substance in allopurinol causes this. This case may actually cause inflammation in the liver, as well as necrosis, a condition where the cells devour some other cells because of misidentifying them for an enemy.


This one is actually caused by the physical blockage of the pathway of bile. This may cause indigestion and more imbalance all throughout the body.

What to do now?

Truthfully, everyone may be troubled by fear when it comes to the side effects of allopurinol. The liver destruction, homeostasis disturbance and morbid illnesses are only a few of its side effects. Certainly, if you have already depended on allopurinol all your life, you’re asking now “what else can I do? Is there a substitute for allopurinol?”

Luckily, there is some substitute for the allopurinol. There’s still hope to treat the condition. This may be done by retreating the root cause of the hyperuricemia, gout or whatsoever condition that gives you a reason to take allopurinol. This certain root is known as the acidosis.

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