Febuxostat & Allopurinol: Advantages And Disadvantages


Medications are very complicated in nature. For this particular reason, various medications that are meant to be dealing with the very same illness with the use of the same method may differ in dosage, side effects, and effects. Some may have amazing advantages. There are others that are cheaper. Others may be expensive, may have no advantages at all, and are teeming with so many side effects yet are still good in marketing.

This article wishes to compare the allopurinol and febuxostat, the two medications, which are commonly used in treating gout. We will be discussing the advantages and disadvantages of each medication. Read on and then you will know which is which between the two.

The Advantages of Febuxostat over Allopurinol in Terms of Dosage

In the actual fact, Febuxostat is said to be capable of doing the job of the allopurinol in even just 40 milligrams. We know that the allopurinol is at least 100 milligrams every day. The advantage here is that the febuxostat loads the kidneys, as well as the liver in a way that the allopurinol does. Remember, they still burden the kidneys and liver.

Furthermore, this has something to do with the medicines’ mechanism of action. Additionally, both of them are xanthine oxidase inhibitors. This just means that their own effectiveness derives from the fact that they may bond with the xanthine oxidase to disturb the production of uric acid.

The xanthine oxidase, as we know is the enzyme that is necessary for breaking down purine into its simpler form. The main difference is that the allopurinol is not discerning and may unintentionally bond with the other proteins, which aren’t purine while the febuxostat may only bond with the purine. Henceforward, the 100 milligrams of allopurinol is overwhelmed by just 40 milligrams of febuxostat.

Remember: They don’t flush the uric acid out nor liquefy the uric acid crystals. The body does this particular task or job. The febuxostat and allopurinol solely disrupt the production of the uric acid.

The Advantages of Febuxostat over Allopurinol in Terms of Side Effects

Both medications have side effects. Both of them has the potential of inflicting a very long list of severe and minor disorders. Both of which may distress the body’s balance. Aforementioned earlier, they distress the xanthine oxidase. Due to this, the uric acid will not get manufactured, just like how the urine will not get processed into its usable form. This may further disturb the balance in the body through slowing and even halting the process of the cell reproduction.

This particular disruption may destroy the balance in the body. If the body’s pH is disturbed, the uric acid will fluctuate. This may affect the body as a whole! Moreover, the fluctuation of the uric acid alone may cause acidosis. The body will be filled with free radicals as the blood’s pH reduces. This may lead to cell destruction, which may worsen the uric acid complications as the cells release purine if they die.

Moreover, the acidosis may cause the breach of the cell membranes if the cells don’t completely die. This may lead to the insulin resistance and ultimately diabetes.

Free radicals may also lead to the thickening of the blood. Furthermore, blood cells membrane will be positively charged. The free radicals, like hydrogen, will be negatively charged. Apparently, the blood cells will separate with each other as the same charges resist. Nevertheless, when the free radicals stick together, this may cause the repulsive force to get weaker. The thick blood is an extra burden to our heart and may cause hypertension. Simply, both medications may cause various side effects, which may affect the body.


The Febuxostat is comparatively better than the allopurinol. We can set this as an example, it is better to fall from a hundred floor, than to fall from a thousand floor building. However, we know that both of the falls may cause death.

The decision is actually on you. Will you take allopurinol, which may cause harm to you? Or are you going to take Febuxostat, which may cause lesser harm? Or, will you look for some other alternative medications for gout? I think the latter one is the best thing to do!


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